Investigating the role of gut microbiota in diabetic nephropathy through plasma proteome mediated analysis.

ABSTRACT: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and poses significant threats to individuals with diabetes. The concept of gut-kidney axis has gained increasing attention in recent years and the in the occurrence and development of DN, alterations in the gut microbiota also plays a crucial and indispensable role. However, the specific causal relationships between various gut microbial communities and DN, as well as the underlying molecular mechanisms, remains unclear. This study utilized data from genome-wide association studies. After screening for qualified instrumental variables, mendelian randomization causal analyses were performed by inverse variance weighting, MR-Egger, weighted median, weighted mode and MR-RAPS methods. Additionally, sensitivity analyses s

SUBMITTER: Fu S 

PROVIDER: S-EPMC11828962 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature