Co-administration of polyethylene glycol with binge ethanol reduces markers of intestinal and hepatic inflammation in C57BL/6J mice by diminishing ethanol absorption through the intestinal wall.

ABSTRACT:

Background

Therapeutic options for managing intestinal and hepatic inflammation associated with alcohol consumption, a prevalent health problem worldwide, remain unavailable. This study examines the potential efficacy of polyethylene glycol (PEG) in mitigating the intestinal and hepatic damage, employing a mouse model for assessment.

Methods

First, the mixture of ethanol (4 g/kg body weight) and PEG (2 g/kg body weight) or an equivalent volume of vehicle was administered orally alcohol consumption.

Results

Acute alcohol consumption was found to damage not only the liver but also the small intestine, as evidenced by histological findings and mRNA expression analysis of inflammatory cytokines. We also identified impaired motor function in the mouse model of binge drinki

SUBMITTER: Ryu T 

PROVIDER: S-EPMC11828973 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature