Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders.

ABSTRACT: Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual heterogeneity among patients with psychiatric disorders limits trans-diagnostic studies with case-control designs, aimed at identifying clinically promising neuroimaging biomarkers. This study aims to identify neuroanatomical differential factors (ND factors) underlying gray matter volume variations in five psychiatric disorders. We leverage 4 independent datasets of 878 patients diagnosed with psychiatric disorders and 585 healthy controls (HCs) to identify shared ND factors underlying individualized gray matter volume variations. Individualized gray matter volume variations are represented with the linear weighted sum of ND factors, and each case is

SUBMITTER: Han S 

PROVIDER: S-EPMC11828988 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature