Pan-serological antibodies and liver cancer risk: a nested case-control analysis.

ABSTRACT: Recently, studies have reported that pan-viral serology signatures may be predictive for liver cancer development. However, whether these same findings are observed for prospective studies has not been previously investigated. The nested case-control analysis included 191 persons who developed liver cancer and 382 controls from the PLCO prospective cohort. The presence of circulating antibodies, measured by VirScan, was determined in serum samples obtained at study recruitment. The presence of antibodies was compared between cases and controls using multivariable conditional logistic regressions, and prediction models were used to estimate whether exposures predicted liver cancer development. No significant associations were found between antibodies to viruses, bacteria or allergens and li

SUBMITTER: Watling CZ 

PROVIDER: S-EPMC11828989 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature