The association between sex hormones and bone mineral density in US females.

ABSTRACT: Osteoporosis and osteoporosis-related fractures exhibits a higher prevalence among females, particularly those aged 50 and above, implying a potential association between sex hormones and bone mineral density (BMD). However, the precise role of sex hormones in BMD remains elusive. Meanwhile, estradiol-to-testosterone ratio (E₂/T ratio) or testosterone-to-estradiol ratio (T/E₂ ratio) is a new biomarker of sex hormone milieu. We investigated whether sex hormones, E₂/T ratio and T/E₂ ratio were associated with BMD or fractures risk in US females. This study is a cross-sectional study, and the data sourced from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 cycle. This study primarily focuses on females aged 50 and above, emp

SUBMITTER: Tian X 

PROVIDER: S-EPMC11829004 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature