In vitro and in vivo assessment of a new acellular human amnion/chorion membrane device for guided bone regeneration.

ABSTRACT: Thanks to its unique biological properties, the human amniotic membrane (AM) has shown promising results for guided bone regeneration (GBR), but displays some limitations such as poor space-maintaining ability. This study thus aimed to develop a new amnion/chorion membrane (ACM), with better mechanical properties as well as comparable or improved biological properties for GBR. We first developed a new decellularization method of ACM (DL-ACM) which was validated by DNA staining and quantification, and its cytocompatibility was established in vitro. The thickness of DL-ACM was significantly increased over thirty-fivefold, and its tearing strength and compression strength significantly increased more than tenfold compared to the decellularized AM (DL-AM). In vivo, DL-ACM demonstrated its bioc

SUBMITTER: Galvez P 

PROVIDER: S-EPMC11829051 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature