MPFC DCC coupling with CaMKII⁺ neuronal excitation participates in behavioral despair in male mice.

ABSTRACT: A longed lack of control over harmful stimuli can lead to learned helplessness (LH), a significant factor in depression. However, the cellular and molecular mechanisms underlying LH, and eventually behavioral despair, remain largely unknown. The deleted in colorectal cancer (dcc) gene is associated with the risk of depression. However, the therapeutic potential and regulation mechanism of DCC in behavioral despair are still uncertain. In this study, we showed that depressive stimulators, including LH, lipopolysaccharide, and unpredictable chronic mild stress, triggered an elevation in DCC expression in the medial prefrontal cortex (mPFC). Additionally, elevated DCC expression in the mPFC was crucial in inducing behavioral despair, as evidenced by the induction of behavioral despair in norm

SUBMITTER: Cheng P 

PROVIDER: S-EPMC11829057 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature