Neurofilament light chain level is associated with lifetime suicidal behaviors.

ABSTRACT:

Background

Suicide is among the severe outcomes of mental illness and has been reported to be associated with neurodegeneration and cognitive impairment. The blood neurofilament light chain (NfL) level is a biomarker of neuronal damage in neuropsychiatric disorders. This study investigated whether the NfL levels are associated with lifetime suicidal behaviors and whether this level is higher in patients with major depressive disorder (MDD) compared with healthy controls.

Methods

In this cross-sectional study, we included 73 patients with MDD and 40 age- and sex-matched controls. The blood NfL levels were measured using an enzyme-linked immunosorbent assay. We compared the NfL levels between patients with MDD and controls and performed regression analysis to evaluate the asso

SUBMITTER: Cheng YC 

PROVIDER: S-EPMC11829164 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature