A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.

ABSTRACT:

Background

Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined.

Methods

Bidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations.

Results

Forward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.0013). The estimated effect value ( β$$ \beta $$   =$$ = $$  -0.0440) suggests that for every 1-unit increase in tea intake, there is a 0.044-unit decrease in SUA levels. However, the

SUBMITTER: Yan W 

PROVIDER: S-EPMC11829186 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature