RNF213 p.Arg4810Lys (c.14429G>A) is associated with extracranial arterial stenosis.

ABSTRACT: Ring finger protein 213 (RNF213) p.Arg4810Lys (c.14429G > A) is associated with intracranial artery stenosis; however, its association with extracranial artery stenosis remains unknown. We aimed to elucidate the clinical significance and association of RNF213 p.Arg4810Lys with stroke subtypes, extracranial artery stenosis, and maximum intima-media thickness. A cohort of 600 patients with stroke prospectively collected over 1 year was assessed for the presence of RNF213 p.Arg4810Lys. A total of 1202 patients served as controls. The association of RNF213 p.Arg4810Lys with various stroke subtypes was studied. In sub-analyses, the association of RNF213 p.Arg4810Lys with intracranial artery stenosis/extracranial artery stenosis and maximum intima-media

SUBMITTER: Shimada D 

PROVIDER: S-EPMC11829204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature