Brain connectivity in individuals with migraine resets during the headache phase: a whole-brain connectivity study.

ABSTRACT: Episodic migraine is reflected by cyclic changes in behavior and cortical processing. We aimed to identify how functional connectivity changes over the entire migraine cycle. By using longitudinal neuroimaging and a whole-brain connectivity analysis approach, we tested 12 episodic migraine patients across 82 functional MRI recordings during spontaneous migraine headaches with follow-up measurements over the pain-free interval without any external stimulation. We found that the functional connectivity linearly increased over the interictal interval. In the prodromal phase, we observed the strongest connections between the anterior agranular insula and the posterior orbitofrontal cortex with sensory, motor and cingulate areas. The strength of the connections dropped during the headache. Peak

SUBMITTER: Schulz E 

PROVIDER: S-EPMC11829205 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature