Multilevel Stressors and Systemic and Tumor Immunity in Black and White Women With Breast Cancer.

ABSTRACT:

Importance

The mechanisms through which chronic stressors may be associated with tumor biologic characteristics, immune response, and health disparities remain insufficiently understood.

Objective

To investigate the proteomic, transcriptomic, and genomic effects associated with multilevel chronic stressors (perceived stress, perceived inadequate social support, perceived racial and ethnic discrimination, and neighborhood deprivation) in Black and White women with breast cancer.

Design, setting, and participants

This cross-sectional study was conducted from February 28, 2012, to September 5, 2023, in which blood samples, breast tumors, and adjacent noncancerous tissues were collected from women with breast cancer. Participants, recruited at 2 Baltimore, Maryland, hospi

SUBMITTER: Harris AR 

PROVIDER: S-EPMC11829235 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature