Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case-control study.

ABSTRACT:

Background

Klotho is a kidney-derived protein that is involved in various kidney diseases. The role of serum soluble Klotho (sKlotho) in the anemia of patients undergoing hemodialysis has not been well characterized.

Objective

We aimed to characterize the relationship between sKlotho and hemoglobin (Hb) levels in this group of patients.

Design

A single-center cross-sectional study of 208 patients undergoing maintenance hemodialysis (MHD) and 50 healthy controls was performed between June 1 and 31, 2023.

Methods

Demographic information and biomedical parameters, such as age, body mass index, medication use, and their Hb, albumin, interleukin-6, and sKlotho concentrations, were obtained. Patients undergoing MHD were allocated to a group that achieved the Hb targe

SUBMITTER: Liu QF 

PROVIDER: S-EPMC11829302 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature