Adjuvant treatment after neoadjuvant chemoradiotherapy and surgery in patients with esophageal squamous cell carcinoma: a real-world study.

ABSTRACT:

Background

Neoadjuvant chemoradiotherapy (NCRT) combined with surgery is the standard treatment option for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, whether adjuvant chemotherapy (AC) administered postoperatively has a survival benefit remains inconclusive.

Objectives

To investigate whether AC is necessary after NCRT and esophagectomy and determine which patients might benefit from it.

Design

A retrospective study.

Methods

This retrospective study examined patients with ESCC treated with NCRT followed by radical esophagectomy at three hospitals between March 2016 and December 2022. Patients were assigned into the adjuvant and non-adjuvant therapy groups based on whether they received postoperative AC, allowing the compar

SUBMITTER: Geng Y 

PROVIDER: S-EPMC11829303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature