Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes.

ABSTRACT:

Background

Cardiac autonomic neuropathy (CAN) is a life-threatening complication of diabetes. While obesity is a well-known risk factor of dysautonomia, the association between CAN and body fat distribution has not been fully clarified, especially in autoimmune diabetes (AD).

Aim

To evaluate if the association between CAN and body fat distribution differs between AD and type 2 diabetes (T2D).

Methods

Body fat distribution was evaluated by Dual X-Ray Absorptiometry in 143 people with diabetes (44 with ADand 99 with T2D) undergoing clinical screening for CAN. The association of CAN with markers of ectopic fat distribution was evaluated in multivariate regression models adjusting for confounders and testing for the interaction between diabetes type and CAN.

Results

SUBMITTER: Risi R 

PROVIDER: S-EPMC11829334 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature