Drug transporter mRNA expression and genital inflammation in South African women on oral pre-exposure prophylaxis (PrEP).

ABSTRACT: Globally HIV remains a major public health problem. In sub-Saharan Africa most new HIV infections occur in adolescent girls and young women. Previously tested antiretroviral drugs as different pre-exposure prophylaxis (PrEP) formulations have shown inconsistent levels of protection against HIV in African women. Besides adherence, biological factors such as drug transporter proteins are increasingly recognized as key modulators of PrEP levels. Drug transporter mRNA expression levels has been significantly correlated to altered PrEP levels in-vitro in different tissues, with inflammation identified as a further modifier of drug transporters mRNA expression and thus PrEP levels. We therefore, aimed to determine possible concordance between drug transporter mRNA expression in the female genita

SUBMITTER: Zondo NM 

PROVIDER: S-EPMC11829381 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature