The striatal matrix compartment is expanded in autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is the second-most common neurodevelopmental disorder in childhood. This complex developmental disorder manifests with restricted interests, repetitive behaviors, and difficulties in communication and social awareness. The inherited and acquired causes of ASD impact many and diverse brain regions, challenging efforts to identify a shared neuroanatomical substrate for this range of symptoms. The striatum and its connections are among the most implicated sites of abnormal structure and/or function in ASD. Striatal projection neurons develop in segregated tissue compartments, the matrix and striosome, that are histochemically, pharmacologically, and functionally distinct. Immunohistochemical assessment of ASD and animal models of autism descri

SUBMITTER: Waugh JL 

PROVIDER: S-EPMC11829417 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature