Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis.

ABSTRACT:

Background

Serum cardiac troponin (cTn) elevation is a well-established phenomenon in sepsis. However, the clinical significance of this phenomenon with high-sensitivity (hs) assays and the current sepsis definition needs to be settled.

Research question

What is the association between early serum cTn levels measured by hs-assays and the risk of short-term mortality in septic patients?

Study design and methods

We conducted a systematic review using a comprehensive PubMed, Scopus, and Embase search. Studies were eligible if they reported association data on early hs-cTn and mortality in an adult sample with sepsis that met the Sepsis-3 definition. For the synthesis of the effect of hs-cTn on mortality, we applied random effect models on the pooled unadjusted and adjust

SUBMITTER: Gajardo AIJ 

PROVIDER: S-EPMC11829436 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature