Pathway-based network medicine identifies novel natural products for Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of dementia, characterized by a complex pathogenesis that complicates the development of effective treatments. Natural products are promising multitarget agents because of their ability to interact with multiple molecular targets. Network-based medicine presents a robust strategy for discovering such agents, which can address the intricate mechanisms underlying AD.

Methods

In this study, we constructed an AD-related pathway-gene network via text mining and pathway database construction. This network facilitated the identification of natural products that target multiple pathways and genes associated with AD. We evaluated the safety profiles of two selected natural products in C57BL/6J mice through assessments of genera

SUBMITTER: Liang Y 

PROVIDER: S-EPMC11829514 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature