Retrospective characterization of seizure semiology and treatment using continuous video-EEG monitoring in neonatal encephalopathy in Uganda.

ABSTRACT:

Objective

Neonatal encephalopathy (NE) is a leading cause of childhood death and disability, particularly in sub-Saharan Africa. Detection of NE-related seizures is challenging. We explored NE seizure semiology and management in Uganda.

Methods

Video-EEG was recorded (days 1-5), seizure semiology reviewed according to ILAE classification and administration of antiseizure medication (ASM) evaluated. Clinicians treated seizures based on the clinical presentation alone.

Results

Among 50 participants, 52% (26) had EEG-confirmed seizures; 70% (18) combined electroclinical/electrographic; 4% (1) exclusively electroclinical; 22% (6) electrographic. Of those with electroclinical seizures (19), 42% displayed >1 semiology. Distribution of seizure semiology was; clonic 34% (11);

SUBMITTER: Proietti J 

PROVIDER: S-EPMC11829619 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature