Clinical, behavioral, and electrophysiological profiles along a continuum of suicide risk: evidence from an implicit association task.

ABSTRACT:

Background

An urgent need exists to identify neural correlates associated with differing levels of suicide risk and develop novel, rapid-acting therapeutics to modulate activity within these neural networks.

Methods

Electrophysiological correlates of suicide were evaluated using magnetoencephalography (MEG) in 75 adults with differing levels of suicide risk. During MEG scanning, participants completed a modified Life-Death Implicit Association Task. MEG data were source-localized in the gamma (30-58 Hz) frequency, a proxy measure of excitation-inhibition balance. Dynamic causal modeling was used to evaluate differences in connectivity estimates between risk groups. A proof-of-concept, open-label, pilot study of five high risk participants examined changes in gamma power afte

SUBMITTER: Lamontagne SJ 

PROVIDER: S-EPMC11829739 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature