Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427.

ABSTRACT: Emerging evidence suggests that the nuclear pore complex can have unique compositions and distinct nucleoporin functions in different cells. Here, we show that Nup107, a key component of the NPC scaffold, varies in expression over development: it is expressed at higher levels in the blastula compared to the gastrula, suggesting a crucial role before gastrulation in Xenopus. We find that depletion of Nup107 affects the differentiation of the early germ layers leading to an expansion of the ectoderm at the expense of endoderm and mesoderm. By analyzing an RNA-sequencing time course, we observed that depletion of Nup107 affects the maternal-zygotic transition by delaying the degradation of maternal transcripts that occurs as zygotic transcription begins. The transcripts are enriched in recogn

SUBMITTER: Kostiuk V 

PROVIDER: S-EPMC11829755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature