Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter.

ABSTRACT: In mammalian ureters, the lamina propria presents as a prominent layer of connective tissue underneath the urothelium. Despite its important structural and signaling functions, little is known how the lamina propria develops. Here, we show that in the murine ureter the lamina propria arises at late fetal stages and massively increases by fibrocyte proliferation and collagen deposition after birth. WNT, SHH, BMP4 and retinoic acid signaling are all active in the common mesenchymal progenitor of smooth muscle cells and lamina propria fibrocytes. However, around birth, the lamina propria becomes a target for epithelial WNT and SHH signals and a source of BMP4 and retinoic acid. SHH and WNT signaling promote lamina propria and smooth muscle cell differentiation and proliferation at fetal and e

SUBMITTER: Straube P 

PROVIDER: S-EPMC11829765 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature