Phthalates are detected in the follicular fluid of adolescents and oocyte donors with associated changes in the cumulus cell transcriptome.

ABSTRACT:

Objective

To investigate the follicular fluid (FF) phthalate levels in adolescents undergoing fertility preservation compared with oocyte donors and explore its association with ovarian reserve and cumulus cell (CC) gene expression.

Design

Retrospective study and molecular analysis of CCs and FF.

Subjects

Adolescents (n = 20, 16.7 ± 0.6 years) undergoing fertility preservation and oocyte donors (n = 24, 26.2 ± 0.4 years).

Exposure

Not applicable.

Main outcome measures

Patient demographics, ovarian stimulation, and oocyte retrieval outcomes were analyzed for each group. The FF levels of 9 phthalate metabolites were assessed individually and as molar sums representative of common compounds (all phthalates, ƩPhthalates; di(2-ethylhexyl) phthalate (DEHP)-ass

SUBMITTER: Gokyer D 

PROVIDER: S-EPMC11829829 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature