Effectiveness of AZD7442 (Tixagevimab/Cilgavimab) for Pre-Exposure Prophylaxis Against COVID-19 Hospitalization in Israel During the Omicron Sub-Variant Time Period.

ABSTRACT:

Introduction

The effectiveness of AZD7442 (tixagevimab/cilgavimab) against COVID-19 hospitalizations was determined at 3 and 6 months among immunocompromised individuals in Israel during different variant circulations.

Methods

This was a retrospective cohort study using data from Clalit Health Services in Israel. Immunocompromised individuals eligible to receive AZD7442 300 mg between 15 February and 11 December 2022 were identified. Immunocompromised individuals receiving AZD7442 300 mg as pre-exposure prophylaxis (PrEP) were propensity score (PS)-matched 1:1 to unexposed individuals using a "rolling cohort" approach. Calendar time Cox proportional hazards regression models were performed with adjustment for post-matched unbalanced covariates to estimate hazard ratios (HRs)

SUBMITTER: Hayek S 

PROVIDER: S-EPMC11829863 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature