How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?

ABSTRACT:

Background

Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited amount of label information, several paediatric drug formularies have been developed. This study compares anti-infective drug dosing recommendations across three European formularies.

Methods

Recommendations from three paediatric formularies (German Pediatric Formulary [GPF], SwissPedDose [SPD] and the British National Formulary for Children [BNF]) were collected. Using population growth curves, we simulated one child for each month from 1 month up to 18 years of age. The recommendations from each formulary were used to calculate doses for each simulated child. Equivalence and difference in calculated doses were analysed.

Results

In tot

SUBMITTER: Higi L 

PROVIDER: S-EPMC11829927 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature