TFAP2A-regulated CRNDE enhances colon cancer progression and chemoresistance via RIPK3 interaction.

ABSTRACT: Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face a poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators of various biological processes and have been implicated in cancer progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles in different cancers. However, its specific functions in CC remain unclear. In this study, we identified CRNDE as highly expressed in CC, contributing to tumor progression and drug resistance. Mechanically, CRNDE is regulated by the transcription factor TFAP2A. Additionally, CRNDE inhibits pyroptosis, a form of programmed cell death, by pr

SUBMITTER: Gao X 

PROVIDER: S-EPMC11829933 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature