A systematic review of determinants of breast cancer risk among women with benign breast disease.

ABSTRACT: Benign breast disease (BBD) is associated with heterogeneous breast cancer risk. Identifying key breast cancer risk factors for this population may inform breast cancer prevention or early detection strategies. We systematically searched literature databases PubMed, Embase, Scopus, Web of Science, and the Cochrane Library to identify studies reporting associations of demographic, lifestyle, reproductive, and radiological factors with risk of breast cancer among women with biopsy-confirmed BBD. 67 studies met eligibility criteria. Variation was observed for study time period, exposure measurement, comparison groups, outcomes, and adjustment for confounders, precluding meta-analysis. The literature suggested positive risk associations for age at biopsy, family history, mammographic breast de

SUBMITTER: Burke A 

PROVIDER: S-EPMC11829998 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature