Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer.

ABSTRACT: Breast cancer (BC) is the most common malignancy with a poor prognosis. Radiotherapy is one of the leading traditional treatments for BC. However, radiotherapy-associated secondary diseases are severe issues for the treatment of BC. The present study integrated multi-omics data to investigate the molecular and epigenetic mechanisms involved in post-radiation BC. The differences in the expression of radiation-associated genes between post-radiation and pre-radiation BC samples were determined. Enrichment analysis revealed that these radiation-associated genes involved diverse biological functions and pathways in BC. Combining epigenetic data, we identified radiation-associated genes whose transcriptional changes might be associated with aberrant methylation. Then, we identified potential th

SUBMITTER: Ji J 

PROVIDER: S-EPMC11830005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature