Distinct clinicopathological features and treatment differences in breast cancer patients of young age.

ABSTRACT: The incidence of breast cancer in young women (aged under 40) is on the rise and is associated with more aggressive tumor characteristics and lower survival rates. Breast cancer is most frequently diagnosed in the sixth decade, and most research presents results based on data from older patients. By using large-scale clinico-pathologic and transcriptomic data from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (n = 1932), we aimed to explore age-related differences in treatment, tumor characteristics, and gene expression signatures. Young patients presented more aggressive clinico-pathologic features such as higher histological grade, more frequent lymph node metastasis involvement, and estrogen receptor negativity. Accordingly, age below 40 years was associate

SUBMITTER: Humlevik ROC 

PROVIDER: S-EPMC11830014 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature