Association of cancers with the occurrence and 28-day mortality of sepsis: a mendelian randomization and mediator analysis.

ABSTRACT: Observational studies have indicated an association between cancer and the occurrence of sepsis, with an increased risk of mortality in cancer-related sepsis. However, whether a causal relationship exists between the two remains unknown. Summary statistics of thirteen cancers from the largest available genome-wide association studies (GWAS) of GWAS catalog and FinnGen biobank were extracted for the MR analysis. GWAS data for sepsis and its 28-day mortality were obtained from MRC-IEU. Univariable, multivariable, and reverse MR analyses were employed to explore potential associations between cancers and sepsis and its 28-day mortality. Moreover, a two-step mediation MR analysis was performed to investigate independent positive causal relationships between cancers and sepsis and its 28-day mo

SUBMITTER: Cheng D 

PROVIDER: S-EPMC11830041 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature