Theoretical analysis of lipase-enzymatic DKR model for racemic (R)- and (S)- ibuprofen ester in a hollow cylindrical membrane bioreactor.

ABSTRACT: This study examines the semi-analytical expression of a hollow cylindrical fiber membrane bioreactor catalyzed by an immobilized enzyme (lipase), focusing on the dynamic kinetic resolution (DKR) of racemic (R)- and (S)-ibuprofen ester through the homotopy perturbation method (HPM). This method effectively solves the coupled non-linear system of second-order ordinary differential equations (ODEs), incorporating the mass transfer associated with the DKR reaction rate. The DKR rate equations are computed utilizing both enantiomers, which represent the enzymatic hydrolysis of the substrate within the barrier's support matrix, where the racemization term is negligible. Additionally, the corresponding racemization of the unreacted substrate outside the membrane is considered, where the enzymatic

SUBMITTER: Ahmed LN 

PROVIDER: S-EPMC11830055 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature