Gene therapy with feline anti-Mullerian hormone analogs disrupts folliculogenesis and induces pregnancy loss in female domestic cats.

ABSTRACT: For female domestic cats, ovariohysterectomy is the only method of inducing permanent infertility. However, hundreds-of-millions of free-roaming cats globally highlight the necessity for alternative contraceptive approaches. One strategy involves a single injection of vector delivering a fertility-inhibiting protein for lifetime contraception. Recent studies in mice and cats have identified anti-Müllerian hormone as an excellent candidate for this type of contraception. Here, we leverage our recent characterization of the molecular mechanisms underlying human anti-Müllerian hormone synthesis and activity, to generate potent feline anti-Müllerian hormone analogs. Single intramuscular delivery of these analogs to female cats using an adeno-associated viral vector leads to a greater than 1000

SUBMITTER: Stocker WA 

PROVIDER: S-EPMC11830062 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature