Mosaic vaccine design targeting mutational spike protein of SAR-SCoV-2: An immunoinformatics approach.

ABSTRACT:

Introduction

Presently, the development of effective vaccines against SARS-CoV-2 is absolutely necessary, especially regarding the emergence of new variants that cause increasing morbidity and fatalities.

Methods

In the present study we designed a mosaic vaccine targeting the mutational spike protein of COVID-19 using a bioinformatics approach. Various immunoinformatics tools were utilized to provide the highest potential for a mosaic vaccine that could activate immune responses against COVID-19.

Results

The evaluation of the constructed vaccine revealed that it is antigenic and immunogenic as well as nonallergenic. The physicochemical properties also show promising characteristics, including being highly stable and hydrophilic. As expected, the vaccine shows strong i

SUBMITTER: Ysrafil Y 

PROVIDER: S-EPMC11830123 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature