Potential use of DNA methylation in cervical swabs for early ovarian cancer diagnosis.

ABSTRACT:

Introduction

Early diagnosis of ovarian cancer, using cost-effective and non-invasive methods remains an unmet medical need, largely due to unspecific symptoms of the disease.

Objective

Our goal was to identify differentially methylated CpG loci between cervical swabs obtained from patients diagnosed with benign ovarian disease and with malignant pelvic mass.

Methodology

Using Infinium EPICv2 array, we interrogated methylation profiles of 77 cervical swabs. The study cohort was then divided into a training and testing set to develop a diagnostic signature. We applied several strategies to pinpoint CpG sites able to differentiate cervical swabs obtained from ovarian cancer patients and patients with benign ovarian disease.

Results and conclusions

None of the sta

SUBMITTER: Biskup E 

PROVIDER: S-EPMC11830180 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature