Computational development of mushroom-6-glucan/paclitaxel as a synergistic complementary medicine for breast cancer therapy.

ABSTRACT:

Background

Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to the metastasis and chemotherapy resistance is the presence of cancer stem-like cells. We posited that the natural polysaccharide known as 6-glucans, derived from Pleurotus ostreatus, could effectively counteract the chemotherapy resistance associated with cancer stem-like cells in breast cancer.

Methods

We computationally developed a specific dual combinatorial therapy involving 6-glucans and Paclitaxel (PTX) and tested on preclinical 3D mammosphere human tumor models representing receptor-positive and receptor-negative breast cancer. Using this preclinical 3D spheroid technology, we tested the anti-cancer properties of these pre

SUBMITTER: El-Deeb NM 

PROVIDER: S-EPMC11830196 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature