Development of cohort definitions and algorithms to identify patients with Lennox-Gastaut syndrome or Dravet syndrome from real-world administrative healthcare databases.

ABSTRACT:

Objective

To develop cohort definitions and algorithms that can be applied to a range of real-world retrospective data sources in the United States, France, Germany, Italy, Spain, United Kingdom, China, and Japan to identify patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) to aid future research.

Methods

The study was conducted in 3 stages. A targeted literature review was used to identify retrospective healthcare database studies identifying LGS or DS populations and develop overall draft cohort definitions and algorithms. Country-specific research explored the diagnosis codes and antiseizure medications (ASMs) with available indications for LGS or DS, with the findings used to adapt the cohort definitions and algorithms to country-specific settings. Phys

SUBMITTER: Shah D 

PROVIDER: S-EPMC11830299 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature