Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model.

ABSTRACT:

Backgrounds

Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a condition characterized by transient left ventricular dysfunction without coronary artery obstruction.

Methods

We utilized label-free quantitative proteomics to analyze protein expression in a murine model of TTC, induced by a high dose of isoproterenol (ISO) injection.

Results

We found that a single high dose of ISO injection in mice could induce stress-related cardiac dysfunction.The proteomic analysis revealed 81 differentially expressed proteins (DEPs) between the ISO and control groups-39 were upregulated, and 42 were downregulated. Key pathways enriched by Gene Ontology (GO) analysis included collagen fibril organization, cholesterol biosynthesis, and elastic fiber asse

SUBMITTER: Tian L 

PROVIDER: S-EPMC11830371 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature