B Cell Receptor Repertoire Analysis of the CD21^lo B Cell Compartment in Healthy Individuals, Patients With Sjogren's Disease, and Patients With Radiographic Axial Spondyloarthritis.

ABSTRACT: B cells with low or absent expression of CD21 (CD21^lo B cells) gained attention due to their expansion in the peripheral blood of patients with immune-mediated, rheumatic diseases. This is not only observed in typical autoimmune diseases like systemic lupus erythematosus and Sjögren's disease (SjD) but also in radiographic axial spondyloarthritis (r-axSpA), which is considered an autoinflammatory disease. To gain more insight into the origins of the heterogeneous CD21^lo B-cell population, and its relation to the plasmablast (PB) compartment, we profiled the B-cell-receptor (BCR) repertoire in CD27^- and CD27⁺ fractions of CD21^lo B cells and early PBs using next-generation sequencing. Populations were sorted from peripheral blood of heal

SUBMITTER: Wilbrink R 

PROVIDER: S-EPMC11830390 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature