Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.

ABSTRACT: Purpose: Incidents, such as nuclear facility accidents and the release of a 'dirty bomb', might result in not only external irradiation of personnel, but additional internal exposures through concomitant inhalation and/or ingestion of radioactive particulates. The purpose of this study was to define the impact of such a combination of radiation injuries on the hematopoietic niche.Material and methods: To assess changes in the murine hematopoietic system, we used a combined exposure of total body irradiation (TBI, 6 Gy) followed immediately by an internal (intraperitoneal) administration of 100 µCi of soluble ¹³⁷Cs. We then evaluated acute survival in combined versus single modality exposure groups, as well as assessing hematopoietic function at 12 and 26 wee

SUBMITTER: Calvi LM 

PROVIDER: S-EPMC11830395 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature