Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy.

ABSTRACT: Bone fractures and bone loss represent significant global health challenges, with their incidence rising due to an aging population. Despite autologous bone grafts remain the gold standard for treatment, challenges such as limited bone availability, immune reactions, and the risk of infectious disease transmission have driven the search for alternative cell-based therapies for bone regeneration. Stem cells derived from oral tissues and umbilical cord mesenchymal stem cells (MSCs) have shown potential in both preclinical and clinical studies for bone tissue regeneration. However, their limited differentiation capacity and wound healing abilities necessitate the exploration of alternative cell sources. In this study, we generated induced pluripotent stem cells (iPSCs) using a safe, nonviral

SUBMITTER: Vembuli H 

PROVIDER: S-EPMC11830513 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature