Gut-derived appetite regulating hormones across the anorexia nervosa spectrum.

ABSTRACT:

Background

Appetite-regulating hormones are implicated in anorexia nervosa (AN) pathophysiology, however, data are limited for appetite-regulating hormones across the AN weight spectrum. We aimed to investigate fasting and post-prandial concentrations of appetite-regulating hormones - peptide YY (PYY), cholecystokinin (CCK), and ghrelin - among adolescent and young adult females across the AN weight spectrum, specifically those with AN and Atypical AN, and healthy controls (HC).

Methods

Participants (N = 95; ages 11-22 years) included 33 with AN, 25 with Atypical AN, and 37 HC. AN was differentiated from Atypical AN by BMI < 10th percentile for age and sex (if <18 years) or < 18.5 kg/m²(if ≥18 years). Blood samples were collected fasting and 30, 60 and 120 minutes

SUBMITTER: Muhammed M 

PROVIDER: S-EPMC11830529 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature