Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients' ability to carry out daily activities, mental health, and life expectancy. Current treatments for RA are limited in terms of duration, efficacy, and adverse effects. PD-L1 is a checkpoint protein that plays important roles in immune regulation and has been implicated in the initiation and progression of multiple autoimmune diseases.

Method

In a previous study, we demonstrated that intra-articular injection with adeno-associated virus (AAV) vectors encoding wild type PD-L1 improved local inflammation in the joint in the collagen-induced arthritis (CIA) mouse model of RA. To further improve efficacy, we explored AAV-mediated delivery of the s

SUBMITTER: Li W 

PROVIDER: S-EPMC11830590 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature