Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats.

ABSTRACT:

Introduction

Dietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. Direct comparison between the effects of Rsv and CR on brain health is lacking, with limited knowledge on their sex-specific effects. Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.

Methods

Here, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (

SUBMITTER: van Rooij JRA 

PROVIDER: S-EPMC11830597 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature