Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering.

ABSTRACT:

Background

The advent of biologics has significantly transformed treatment strategies for neuromyelitis optica spectrum disorder (NMOSD). However, there are no biomarkers that predict relapses associated with steroid tapering; therefore, it is critical to identify potential indicators of disease activity. In this study, we collected peripheral blood mononuclear cells (PBMCs) from NMOSD patients during steroid tapering and performed bulk RNA sequencing to analyze changes in immune dynamics caused by steroid reduction.

Methods

PBMCs were collected at 3-5 timepoints from 10 NMOSD patients at our hospital (including one relapse case), and bulk RNA sequencing was performed. All patients were positive for anti-AQP4 antibodies and had no history of biologic use.

Results

In o

SUBMITTER: Yamamura R 

PROVIDER: S-EPMC11830620 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature