The Effects of Vitamin D on Muscle Strength Are Influenced by Testosterone Levels.

ABSTRACT:

Background

Although the role of vitamin D receptor (VDR) in muscle mass and strength is well established, the effects of vitamin D (VD) on muscle remain controversial due to various factors. Herein, the influence of sex on the effects of VD on muscle function and the underlying reasons was explored.

Methods

Male and female Sod1 gene knockout (SKO) mice, serving as a model for skeletal muscle atrophy, were treated with the VD active analogue calcipotriol, and RNA sequencing was employed to investigate this potential signalling pathway. The National Health and Nutrition Examination Survey (NHANES) database was utilized to explore whether testosterone affects the correlation between VD and grip strength in human participants. Experiments involving C2C12 cells and castrated male

SUBMITTER: Yang A 

PROVIDER: S-EPMC11830628 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature