Genotype 3 is linked to worse liver disease progression in hepatitis C patients even after SVR following DAA therapy.

ABSTRACT:

Background and aims

HCV genotype (GT) 3 is associated with rapid liver disease progression. However, the liver disease progression and its risk factors in patients with HCV GT 3 infection after sustained virological response (SVR) following direct-acting antivirals (DAAs) remain unclear. Therefore, we aimed to investigate the liver disease progression of patients with GT 3 after SVR.

Methods

This was a retrospective cohort study of patients with HCV infection who achieved SVR by DAAs. The clinical outcome was overall liver disease progression (OLDP), defined as newly diagnosed compensated liver cirrhosis, decompensated liver cirrhosis, or hepatocellular carcinoma. The incidence of OLDP was evaluated by Kaplan-Meier analysis. Cox regression analysis identified the risk factor

SUBMITTER: Ran X 

PROVIDER: S-EPMC11830654 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature