Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer.

ABSTRACT:

Objective

Gastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.

Methods

Using a two-sample Mendelian Randomization method, this study revealed the potential causal effect of atrial fibrillation (AF) on gastric cancer (GC) risk by constructing a genetic instrument containing 136 AF associated SNPs. Subsequently, analysis identifies 62 AF-GC co-associated genes and constructs a protein-protein interaction network of key genes. High-throughput sequencing data were further used to analyze the association between the two and their impact on the survival outcome of gastric cancer.

Results

The results showed that AF was negatively associated with gastric cancer, and further analys

SUBMITTER: Sicheng Z 

PROVIDER: S-EPMC11830663 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature