Exploring the exoproteome of the parasitic nematode <i>Anisakis simplex</i> (s. s.) and its impact on the human host - an <i>in vitro</i> cross-talk proteomic approach.

ABSTRACT:

Introduction

Anisakis simplex sensu stricto (s. s.) is one of the most widespread parasitic nematodes of marine organisms, with humans as accidental hosts. While many studies have explored nematode biology and host interactions, the role of extracellular vesicles (EVs) as signaling molecules in parasitic nematodes is less understood.

Materials and methods

Therefore, the proteins present in the EVs of A. simplex (s. s.) (Anis-EVs) were identified. In addition, a cross-talk proteomic approach was used to identify differentially regulated proteins (DRPs) in the proteome of the human intestinal epithelial cell line (Caco-2) co-cultured with L3 larvae of A. simplex (s. s.) or directly exposed to two concentrations (low or high) of Anis-EVs. In addition, DRPs were identified in th

SUBMITTER: Stryinski R 

PROVIDER: S-EPMC11830668 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature