Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naive, first-episode adolescent MDD.

ABSTRACT:

Objective

Adolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. The aim of this study is to investigate whether dFC patterns will be changed by antidepressant treatment, as well as whether baseline dFC pattern could predict treatment response in adolescent MDD patients.

Method

We included 35 drug-naïve, first-episode MDD adolescents (age 14.40 ± 1.24; 8 males and 27 females) and 24 healthy controls (HCs, age 14.21 ± 1.41; 11 males and 13 females). All MDD adolescents received 6 weeks of antidepressant treatment. Resting state and T1 MRI data were collected in MDD adolescents before and after treatment and in HCs. Indep

SUBMITTER: Ran M 

PROVIDER: S-EPMC11830731 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature